Comparing the virtues of the gain and loss models, we believe the gain model more closely represents the real world situation for the following reasons.
Phenotypic differences between knock-in and transgenic models are also evident, and clinical observations will eventually validate which model more closely represents human PIK3CA mutated breast cancer.
As previously reported, the 5T2MM model more closely represents human MM, characterized by a moderate progressive course of the disease and induction of osteolytic lesions, while the 5T33MM model represents an aggressive, rapidly progressive variant (Vanderkerken et al, 1997; Radl et al, 1988).
Using these results, it is possible to select the mouse model that most closely represents a group of human breast cancer for the signaling pathways of interest.
This tumor model recapitulates several features of advanced human BC, including the ability to generate spontaneous lung and lymph nodes metastases, and may be advocated as the model most closely representing the clinical situation in human cancer [ 37, 38].
This is a more conservative selection procedure than our previous study, where we took the best model from the five lowest energy models, but this more closely represents the way in which models would be selected in practice.
This design allowed for greater translation of the findings to clinical practice in that there were no artificial restrictions on additional treatment in either arm, and the comparison group we evaluated more closely represents models of care that could be implemented in practice.
The auctions are modeled to closely represent the auction design foreseen in the German Renewable Energy Sources Act (EEG, 2017) and replicate their parameters.
