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On the single cell level, the rate-reduced model closely mimics the spiking dynamics (Fig. 5) and filter properties (Fig. 6) of the full spiking neuron model.

The figure shows that the model closely mimics the ideal curve when the proportion of malicious nodes in the test set is also 0%, same as in the training set.

These findings demonstrate that the low-dose MIA rat model closely mimics the pathological features of progressive human OA.

The 4T1 orthotopic model closely mimics the progressive forms of estrogen-insensitive human metastatic breast cancer [ 16].

This mouse model closely mimics human DCIS because DCIS initiates inside the ducts, which provide a natural microenvironment for malignant growth.

Although our procedure is time consuming, it is simple and systematic, ensures that the reduced model closely mimics the transients of the original model and is scalable to a large model.

In the present study, the effects of transient vs. sustained GDNF delivery by encapsulated cells were evaluated in a bilateral animal model, closely mimicking advanced PD.

We addressed this question by testing melatonin treatment in a recently described rat model closely mimicking WMD observed in very preterm neonates [8].

Fig. 3 shows the responses from a typical onset-later activity (OL) unit and a model closely mimicking its responses.

In conclusion, our work presents a model, closely mimicking the clinical situation, for studies of the osteoblastic function of CRPC both in vitro and in vivo.

The recent advancement of an experimental model closely mimicking human MPO-ANCA associated vasculitis is a major step forward for gaining insight into key pathogenetic mechanisms and for testing new potential therapies [ 59].