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Areas under the concentration-time curves generated by a physiologically-based pharmacokinetic model changed substantially (>25%) in several tissues when model parameters describing compartmental volumes and blood flow rates were switched from literature to our experimentally derived values.
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Verizon, whose business model has changed substantially since 2010, now supports aspects of the 2015 Order with which even some of the advocacy groups took issue.
In the third model all available covariates, including 25D, log(10 PTH and log(10 FGF23, where appropriate, and prevalent disorders, as well as BMI, were included to test if the association in model 2 changed substantially.
Another reason a predictive model's assumptions may no longer be valid is if the analyst didn't include a key variable in the model, and that variable has changed substantially over time.
Since that time, the costs of STIs have changed substantially, rendering the 1992 CDC model somewhat dated.
The model of how cartilage is replaced by bone has changed substantially in the past few years.
The comparison microscopes in the N.Y.P.D. crime lab are more powerful than Goddard's model was, but many of the techniques the lab uses haven't changed substantially in decades.
If the estimate changed substantially, the subject deleted in that run was influential to the model fit.
Following model revisions to incorporate additional population subgroups, the conclusions about the distribution of new infections have changed substantially.
That position has changed substantially.
And men have changed substantially.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com