Sentence examples for model cell kill from inspiring English sources
For example, we could investigate the effects of changing the functional form used to model cell kill in equation (2).
The seminal contribution in modeling the effects of chemotherapy on glioblastoma multiforme was made by Murray and coworkers (Tracqui et al. 1995), who used a reaction-diffusion equation to model tumor growth and included a term modeling the cell kill kinetics of a chemotherapeutic agent.
We showed that large fluctuations on radio-sensitivity over tumor volumes may not matter clinically, thus validates any Poisson models using cell killing effects over tumor volumes.
An adaptation of Skipper's log cell kill model of tumour response to chemotherapy was applied to serial tumour measurements of 46 locally advanced primary breast carcinomas undergoing neoadjuvant chemotherapy.
Here, we restricted the damaging effect of chemotherapy to the proliferating stem cell sub-compartment of the hybrid model and applied the stem cell kill rates estimated for the former ODE model.
Our study presents a model for MDR cell killing using a compound of natural origin.
This low level of NF-κB activation was quantitatively equivalent to a previous report about challenging the established bovine MEC model cell MAC-T with heat killed S. aureus (1.3 fold induction in FCS containing medium, [ 44]).
Theoretical modelling of Norton Simon (1986) clearly indicates that cell kill can be substantially increased by the sequential use of cytotoxic regimens.
> Models of tumour growth and chemotherapy induced tumour cell kill are typically incompatible with the notion that more intense therapy can be less effective.
From a population PK model, central compartment concentrations (Cdrug) are derived and induce cell kill by a linear (Slope Cdrug (t)), or by a (sigmoid) Emax drug effect.
We believe the 95% inhibition figure to be important, as this is the level of tumour cell kill required for most logarithmic kill models to show effects (Goldie and Coldman, 1979).
