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Unlike the random draw model, the predictions of the neutral model can be altered by varying its parameters, m and d, which need to be assigned values.
Moreover, the finding that the clefting pathology in this model can be altered by manipulation of Fgf signaling during embryonic facial development could one day lead to directed early pharmacological interventions, rectifying facial growth and preventing the need for repetitive surgeries.
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The access control requirements can be varied; trust models can be altered or changed, and even models for establishing trust in the system can be changed.
The model, however, can be altered to consider different scenarios of medication prescription and consumption.
The lower-price manufacturers use preassembled models that can be altered slightly (a jacuzzi here, a shower there).
In glaucoma models, the PERG can be altered before histological loss of RGCs; PERG alterations may be either reversed with moderate IOP lowering or exacerbated with moderate IOP elevation.
Another aspect is the histological subtype associated with various tumors in GEM models and the metastatic ability can be altered with background [ 12].
In SimHerd, there are decision variables related to the reproductive performance and they can be altered to model the reproductive status of the cow.
In many models the performance of the pacemaker can be altered by using radio-frequency signals to alter its programmed settings.
Further studies are required to show if TLX is a true contributing factor for cancer metastasis by using NB animal models, and whether the metastatic capacity can be altered by depletion of TLX.
However, our model shows that the predicted scrapie dynamics can be altered when considering conflicting associations of the PrP genotype with fitness traits other than scrapie susceptibility, even if they are weak.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com