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We have presented strong experimental evidence that WM130, a novel matrine derivative, could suppress the activation of HSCs and hepatic fibrosis induced both in cytological experiments and in the DMN-induced rat model by inducing apoptosis and suppressing deposition of ECM.
Finally, when we created the experimental osteoarthritis model by inducing instability in the knee joints of adult mice of wild-type and C/EBPβ+/− littermates, the C/EBPβ insufficiency caused resistance to joint cartilage destruction.
Therefore we tested argon's impact in an in vitro model by inducing a focal mechanical trauma.
This validation scheme estimates the accuracy of a given classification model by inducing the same number of classifiers as the dataset is comprised of.
Our therapy is based on our previous discovery that A12 could profoundly suppress arthritis in the CIA model by inducing a unique inhibitory T cell [ 18].
Furthermore, we extended the model by inducing an additional flare by re-challenging the rats with an additional systemic intravenous injection of SCW (flare 3).
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Anhedonia, a core symptom of depression, was modelled by inducing a decrease in responsiveness to rewards reflected by a reduced consumption and/or preference of sweetened solutions.
Additionally, the use of nasal anti-CD3 ameliorated systemic lupus erythematosus in two different mice models by inducing IL-10.
Circadian disruption can be modelled by inducing 'chronic jet-lag' in animals through exposure to regular shifts in the lighting schedule.
Anhedonia, a core symptom of major depression in humans, is modeled by inducing a decrease in responsiveness to rewards, as reflected by reduced consumption or preference for sweetened solutions [ 31].
Thus, IFN-β prevented pathology in a familial model of PD by inducing autophagy and α-syn clearance.
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