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For model building, all candidate variables were initially screened, one-by-one, using a bi-variable approach [ 32].
Consequently, rather than taking a step-wise approach to model building, all predictors were included in the multivariable regression models.
In the second step of TileProbe model building, all samples from a given array platform in GEO are grouped according to studies and experimental conditions.
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Pauling pressed ahead with his model-building all the same, relying on his unrivalled grasp of the geometry of chemical bonds.
The B-factors are actually of direct relevance – in macromolecular crystallography, thermal motion, crystallographic disorder, even model building errors, all contribute to the B-factor.
After several cycles of multireference alignment, the final alignment used a single reference as it was desirable to fit one atomic model to the thin filament for all class averages and raw repeats that would be used for all subsequent model building.
Following examination of the univariate results we fit a multivariate GEE logistic regression model using an a priori defined model building protocol whereby we included all explanatory variables with a univariate p-value < 0.05.
All predictor variables were used in initial model building.
The Buccaneer software for automated model building.
(1) Model building.
(Automatic model building step, AMB).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com