We present here the structures for two inhibitor peptides, LPFFD and DPFFL, and their structural models bound to fibrillar Aβ14-23 Aβ14-23-40 bandd on transferred nuclear Overhauser effect (trNOE) and transferred residual dipolar coupling (trRDC) data.
To guide the design of subtype-selective ligands for AT2R/AT1R, we constructed the receptor models bound to AII and screened for potential hotspot areas that could be discriminative between the two receptor subtypes.
Given the competition among record companies, the subscription model is bound to be tricky to organize and implement.
Given recent stockmarket turbulence, the KMV model is bound to show some increase in risk.
The calculations were performed on the truncated active site model compound bound to quinoline.
Fig. 4 shows the log Kcond Fe(III L data obtained from the kinetic approach at pH = 8 and the CSV-CLE approach for model ligands bound to Fe(III) in UV seawater.
A molecular regulatory network model is bound to have several parameters, for most of which very little empirical data is available.
Bad models are bound to lead to bad decisions, so the better models we have, the more likely we are to discover and cost-effectively develop drugs that work well to help patients.
Being designed as generic theoretical frameworks SDH models are bound to a certain level of abstractness and detachment.
In the absence of a structured effort to represent available knowledge in a mechanistic way, such models are bound to yield predictions of questionable reliability.
