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RODNEY BROOKS, the 45-year-old director of the Artificial Intelligence Laboratory at the Massachusetts Institute of Technology, has spent most of his career engrossed in the question of how to model biological systems.
The deluge of genomic information would, the theory went, be funnelled into powerful computers, which would then be able to model biological systems, figure out how they went wrong, and design drugs to fix them.
Dynamical systems are frequently used to model biological systems.
Membrane Computing has been used to model biological systems, becoming with time a thorough modeling paradigm comparable, in its modeling and predicting capabilities, to more established models in this area.
The authors concluded that the FO models are more suitable to model biological systems with memory, than their integer-order counterparts.
Many formalisms have been used to model biological systems, in part due to the diversity of phenomena that occur in living systems, and also due to the multidisciplinarity of the research teams.
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Bialek has an ongoing collaboration with Princeton's Squibb Professor in Molecular Biology Eric Wieschaus, a Howard Hughes Medical Institute researcher and Nobel Prize winner, who has uncovered many of the genes involved in the embryonic development of the fruit fly — a model biological system.
As a model biological system for single cell studies, we have developed and selected a cell line stably expressing a yellow fluorescent chimeric trans-membrane protein.
Based on our positive experience, we propose that the friendly, yet formal, OPM modeling framework is a tool for modeling biological systems, whose adoption would benefit the emerging domain of systems biology.
Moreover, the lack of the process as a stand-alone concept in the OO modeling approach is a major hindrance for modeling biological systems, which are mostly process-intensive.
The ability to derive and manipulate pluripotent stem cells has opened up new avenues for modeling biological systems in both healthy and diseased conditions.
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