Sentence examples for model biological rules from inspiring English sources

To develop the co-culture model, biological rules concerning the inclusion of fibroblasts and serum were derived and integrated into the keratinocyte colony formation model, which will be explained in the following sections.

This new model includes new biological rules about the emergent responses of keratinocytes to various wound injury signals abstracted from the extensive published literature.

To do this the previously developed agent based keratinocyte colony formation model [5] was first extended to an epidermal wound healing (re-epithelialisation) model by including new biological rules about the emergent responses of keratinocytes to various wound injury signals abstracted from an extensive published literature.

In this investigation, the agent-based model was used to capture biological rules governing intercellular interactions in the human epidermis; COmplex PAthway SImulator was used to simulate the expression and signalling of TGF-β1 at the intracellular level and the physical solver was used at the continual level to resolve forces exerted between cells.

We model biological cell renewal using various rules for the movement and differentiation (change of phenotype) of cells based on the type of cell, the type of adjacent cells, and the strength of the morphostat gradient at an adjacent cell.

The experience of developing this integrated model also clearly demonstrated the advantages and disadvantages of the simple biological rules in the agent based model and the mechanisms in the COPASI model.

In the next section, we present the TGF-β1 COPASI model and describe the modifications introduced to the biological rules previously used in our keratinocyte colony formation model [5].

In the integrated model, the dynamic interactions between NHK and the various ECM components were simulated using both biological rules at the cellular level and the COPASI model at the sub-cellular level, however the COPASI model was given a higher priority than the cellular rules.

In other words, at a certain model iteration (denoting 30 min in reality), cells first execute their biological rules (e.g. cell proliferation and migration) then the physical rules are executed.

Most of the biological rules used in the previous keratinocyte colony formation model [5] were kept un-changed except for slight alterations to simulate cell behavior in the human epidermis in 3D as opposed to in 2D culture.

Most of the biological rules used in the previous keratinocyte colony formation model [5] were slightly altered in this work to capture cell behaviour in the human epidermis as opposed to 2D culture.