This model best reflects the association between frailty, its indicators and its underlying factors, in that particular indicators are explained by both a dominant general factor, (i.e. frailty), as well as seven specific factors, and these factors are mutually uncorrelated (see Figure 2).
The accounting profession allows for some discretion here, but generally an accelerated depreciation model should only be implemented when it is felt that this model best reflects the actual value of the asset.
It is also important to consider whether diabetic mouse models should be included for the evaluation of public health vaccines, and if so, which of the available diabetic mouse models best reflects the increased susceptibility of the at-risk human population.
A key question that continues to be debated is whether human cancer xenografts or murine transgenic models best reflect the human disease in terms of biology and predictions of efficacy of therapeutic agents (Becher et al, 2006; Dennis, 2006; Garber, 2006; Sausville et al, 2006; Sharpless and DePinho, 2006).
Therefore, just like familial breast cancer, the model that best reflects familial ovarian cancer might be a "common disease-multiple rare alleles" model.
However, we chose the partially crossed model to best reflect this particular setting.
In the glycerol AKI model that best reflects kidney damage during myoglobinuric AKI, heme oxygenase-1 was detectable in plasma and the renal cortex, and these changes were associated with an approximately 10-fold increase in renal heme oxygenase-1 mRNA.
Fractional polynomial modelling compares models of different combinations of linear and non-linear transformations of door-to-balloon time to identify those models that best reflect the association of time to treatment and mortality.
Further, for diseases in which human clinical studies are not ethical, selection of animal models that best reflect or mimic human molecular responses would provide increased confidence in the selection or testing of therapeutics.
Obviously, models generated by the same modelling technique as the reference model generally performed best, reflecting a "home advantage" over models generated by a different modelling technique than the reference model.
