Issues are raised through the study of two examples in which designs are assessed using simulation studies of the power to reject the null hypothesis of the smaller model being correct, when the data are generated from the larger model.
Again, however, the success of this approach relies heavily on the hypothesized inheritance model being correct.
Using PA, no exceptionally strong linkage signals were found, since this value depends on the assumed genetic model being correct.
Statistical methods, such as maximum likelihood (ML) and Bayesian inference, have been shown to be statistically consistent (Rogers 1997), which means they tend toward the correct answer as more data are added to an analysis conditional on the substitution model being correct.
The MI method does rely to a great extent on the imputation model being correct, but providing the data are normally distributed or can be transformed to normality there is a sound theoretical background to how the imputations are generated [ 16].
The probability of the model being correct was 92.5% for the Gaussian and 7.52% for the Hill model, therefore the former was adopted: Emax = -5.1 log10 CFU/g, logEC50 = 1.78, EC50 = 60.3 mg/kg per day, slope = 0.87 (data shown in Table 4 includes only OXA products fitting Hill's model).
