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The appropriateness of model assumptions was checked using diagnostic plots.

Violation of model assumptions was checked in the final models.

Model projections were compared, and the robustness of the revised model projections to different model assumptions, was investigated.

Face validity of the model structure and major model assumptions was undertaken within our modelling team (FK, BS) and with our clinical expert (RW).

However, the validity of the model assumptions was verified in all data: The Patlak model provided a good fit to all measured ROI curves.

Adherence to Rasch model assumptions was determined with analysis of Rasch model fit (infit and outfit), unidimensionality, local independence (principal component factor analysis of the residuals, PCFAR) and differential item functioning (DIF) with regard to participants' age and gender.

If the residual analysis does not indicate that the model assumptions are satisfied, it often suggests ways in which the model can be modified to obtain better results.

Check if the model assumptions are correct and complete.

These model assumptions are visualised in Fig. 2.

The complete model assumptions are shown in Table 4.

STM model assumptions were verified with strain gauge measurements.