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Homeostatic model assessment values for insulin resistance (HOMA-IR) were calculated using the formula stated above.
Studies in humans showed a positive relationship between circulating NGAL concentration and fasting insulin and homeostasis model assessment values.
High-GI diets increased insulin resistance as measured by homeostasis model assessment values in the DIOGenes study, but showed variable associations with the risk of diabetes.
In a study that matched vegetarians and nonvegetarians, nonvegetarians had higher insulin, glucose, and homeostasis model assessment values than vegetarians (23).
Several additional post hoc correlations between baseline measurements of homeostasis model assessment relative to changes in quantitative insulin sensitivity check index, low-density lipoprotein, and small artery elasticity are presented as worsening over time in subjects with higher baseline homeostasis model assessment values, an effect the authors attribute to GlcN.
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On multiple regression analyses to predict serum RBP4, log serum ferritin contributed significantly to RBP4 variance after controlling for BMI, age, and homeostasis model assessment value.
The authors also recognize that it would have been better to measure insulin resistance by homeostatic model of assessment – insulin resistance but, unfortunately, homeostatic model of assessment values were only available in a small percentage of patients.
Homeostatic model assessment (HOMA) values were calculated as an estimate of insulin sensitivity, using the formula fasting plasma glucose (mmol/L)×insulin (µU/ml)/22.5.
To quantify the degree of insulin sensitivity, homeostasis model assessment (HOMA) values were calculated using the validated calculator available at http://www.dtu.ox.ac.uk.ac.uk
The lower panels of Fig. 4 show the profiles of homeostasis model assessment (HOMA) values (glucose concentration (mmol/l)×insulin concentration (mIU/l) divided by 22.5) calculated for each time point.
Decrement of Tissue Polypeptide Specific antigen concentrations best differentiated the Body-Weight loss from the body-weight maintenance in respect to Tissue Polypeptide Specific antigen and HOmeostasis Model Assessment method values.
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