Sentence examples for model assays from inspiring English sources
Compounds that showed promising COX-2 selectivity were further subjected to in vivo anti-inflammatory screening applying formalin induced paw edema (acute model) and cotton-pellet induced granuloma (chronic model) assays using celecoxib and diclofenac sodium as reference drugs.
A structure activity relationship is described for a series of peptides which were synthesised and tested for their activity against two prion disease model assays, an in vitro cellular assay and an in vitro anti-aggregation polymerisation assay.
We are now developing mouse model assays to further characterise the role of the CCL20 CCR6 axis in Treg cell homing in vivo.
The efficacy of metformin alone and in combination with tamoxifen against ER-positive breast cancer was analyzed by cell survival, DNA replication activity, plate colony formation, soft-agar, flow cytometry, immunohistochemistry, and nude mice model assays.
Moreover, the effects of up-regulating NDRG2 expression on the growth of an ESCC cell line were examined by MTT, colony formation, DNA replication activity and nude mouse model assays.
An orthotopic mouse model assayed ability to produce tumours in vivo.
Incorporation of new models, assays and biomarkers has expanded our ability to understand the mechanisms of action underlying microbicide toxicity and efficacy, enabling a more rational selection of drug and formulation candidates.
Concerning 3D angiogenesis models, assays involving Matrigel, a matrix derived from mouse Engelbreth-Holm-Swarm sarcoma, are among the most common commercially available in vitro angiogenesis assays.
In all three models assayed, CD44+CD24low+ cells gave rise to both CD44+CD24low+ and CD44+CD24neg phenotypes in 2D culture with asymmetric growth kinetics.
We also note that despite the known genomic instability of TNBCs [ 68], we observed that all PIK3CA sequence variations persisted between patient primary tumors and xenograft models, and between xenograft models assayed during different sequential passages.
The third model (assay removal, Additional file 1: Figure S1C) removed whole assays at random and was only applied to the PKIS data set, as the number of assays in the HTSFP subsets was deemed too small.
