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The best performing model, as measured by leave-one-out cross validation on the training data, was the 15 NN model with exponential weighting.
By optimizing both the N-aryl acetamide region of the inhibitor and the 4-position of the thiophene we obtained single digit nanomolar compounds, such as 47, which demonstrated an in vivo effect on JNK activity when dosed orally in our kainic acid mouse model as measured by phospho-c-jun reduction.
After optimization of the neural networks in the training dataset, the final best neural network model, as measured by balanced accuracy in the training dataset, was applied to the testing dataset and evaluated.
The predictive power of the full new model as measured by the C-index is 0.781 (A).
Additional file 6: Separation ability of the multivariate logistic regression model as measured by the area under the curve.
The predictive power of the model, as measured by the area under the curve (AUC) of the receiver operating characteristics (ROC) plots was moderate.
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Another way to interpret the results from this network model is to consider the model as measuring the stability of a memory representation, irrespective of the nature of the cognitive task.
The agreement of measured and predicted datasets was good for both models, as measured using various statistical parameters.
Therefore, the single exponential model provides a more accurate model of the data.The same conclusion may be drawn when considering the overall assessment of the utilized models, as measured by the mean and variance of RMSE and (R^2) for the curve fitting tasks over all triplets within the sampled space of the initial conditions.
We have shown the prediction capability of the models, as measured by the RMSE of prediction dataset (Table 1 and Table 3), to forecasts the next influenza season.
Moreover, the effects of landscape gradients in the multiple regression models (as measured by the ηp2) were of the same magnitude, when not clearly larger, than those of temperature (Table 2).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com