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We tried to correct for this bias by normalizing the variable importance scores by the effective variance reduction brought by the model as estimated by cross-validation but it actually deteriorated the performances.

The accuracy of the model, as estimated by cross-validation, was high.

We assigned the best fitting model, as estimated by M RM ODELTEST2, to each of the six loci.

ML analysis revealed a phylogenetic tree with the -lnL of 186099.2 using the GTR + I + G model as estimated using JModelTest.

Model 1, including only type 2 diabetes-associated SNPs, had a discriminative power of 0.591 (p < 1.00 × 10−20 vs null model) as estimated by the ROC AUC.

Finally, we asked whether in the network model, chosen value variability is explained away by the internal dynamics of the model, as estimated by the LFP decomposition.

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In particular, we simulated demographic models as estimated by dadi with selection parameters estimated from the recurrent hitchhiking model (s = 9 × 10−4 and mean λ = 5.0 × 10−10).

The demographic history for each species is modeled as estimated with dadi (table 2), and the rate and strength of selection are taken from the recurrent hitchhiking estimates obtained from the Jensen, Thornton, and Andolfatto (2008) approach (table 4).

To do so, we estimated chimpanzee density using a spatially explicit model, as well as estimating abundance using both capwire and spatially explicit models.

In summary, the kNN QSAR algorithm generates both an optimum k value and an optimal nvar subset of descriptors, that afford a QSAR model with the highest training set model accuracy as estimated by the q value.

The overall ML tree topology for each gene and the concatenated dataset was determined using GarliV0.951 [61] with model parameters as estimated by Modeltest.

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