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Mathematical difficulties related to the Bingham model are overcome thanks to the use of a Lagrange multiplier and an augmented Lagrangian/Uzawa method.
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How some limitations of capillary network models are overcome is discussed.
Moreover the challenge of the definition of an accurate approach to condense finite element models for representing the flexible components in the flexible multibody models is overcome.
The uncertainties caused in Kalman-type filters, due to the inaccurate selection of model parameters are overcome using an EM algorithm.
In the iJO1366 model, these knockouts are overcome by using the isozyme or alternative pathway to synthesize biomass components.
At least until these barriers are overcome, animal models will continue to provide a unique opportunity to consider aspects of drug disposition in the toxicological effects of a given compound.
Thanks to some methods different from those of previous literature, the difficulties brought by fuzzy stochastic mathematical model and impulsive model have been overcome.
The major problem, handling arbitrary variations in the model geometry, is overcome using a modified form of the Woodcock neutral-particle tracking algorithm.
The limitations of the mixture model can be overcome using cardiac arrest data recorded while delivering CPR.
We recently showed that resistance to E1A gene therapy in an ovarian cancer xenograft model could be overcome by downregulating Bcl-2 with a Bcl-2 antisense oligonucleotide [ 18].
The long-term engraftment of human hepatocytes into rodents would be useful for the study of human viral hepatitis, where it might allow the species, technical and size limitations of the current animal models to be overcome.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com