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As a promising species of model animals, the ipNPCs generated in our study may provide an exciting tool to bridge the present gaps in neuroscience studies between rodents and humans.
On the basis of the known importance of other skin appendages (hair follicles, apocrine glands, and sebaceous glands) for wound repair in model animals, the present study was designed to assess the role of eccrine glands in the repair of wounded human skin.
Among the common model animals, the gerbil is the only species in which both InlA/E cadherin and InlB Met interactions are functional.
As an example, Prakash and colleagues [ 78] compared in model animals the anti-anxiety effects of hypericum prepared as gold nanoparticles versus a bulk form and observed more significant effects with the nano-hypericum, even at a 10-fold lower dose.
A recent comparative proteomic study of two distantly related model animals, the nematode Caenorhabditis elegans and the fruit fly Drosophila melanogaster, revealed an unexpectedly strong positive correlation (correlation coefficient of ∼0.8) between the abundances of orthologous proteins in the two organisms (Schrimpf et al. 2009).
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From the three forms of mercury found in aquatic ecosystems, the immunotoxic effects of mercury chloride were examined in the model animal, the blue mussel.
As each person completes a model animal the women gives them a new piece of coloured card.
While model animals epitomise the success of the scientific strategy of reductionism, they may also illustrate the downside.
The larger the distance between the model animal and the species to be modelled (the extrapolation distance), the poorer the generalizability of a study may be.
We show that in the focal ischemia model animals lacking the octapeptide of PrP (PrPΔ32 93) behave like Prnp−/− mice.
As such, the model animals held on the Ark Encounter are approximations of what dogs', cats' and rhinos' ancestors would have looked like.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com