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If model animals have ortholog genes for NXF, they might have advantages for characterization of its function and regulation in vivo.
The studies on model animals have provided much information about how genetic factors regulate the timing of puberty in mammals.
Experiments using model animals have also demonstrated that PEDF could be used to treat a variety of eye diseases that lead to blindness and many types of cancer.
TNBS-induced colitis model animals have been widely used for identifying anti-inflammatory components such as plant extracts [ 12], seed oils [ 13], and probiotics [ 2, 14].
Recent technologic advancements in the transgenic expression of human genes in model animals have led to the generation of many 'humanized' mouse strains for the study of human-specific infectious diseases.
Several studies, involving a variety of different species of farm and model animals, have investigated the host response to Salmonella infection and have successfully identified genes differentially expressed upon infection or gene variants and chromosomal loci associated with immune response traits during infection with Salmonella[ 7, 20, 27, 28].
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The extensive and novel genomic data generated from these non-model animals have revealed much about their underlying molecular mechanisms in response to different environmental stressors [ 13, 17].
The habitat suitability models for individual animals have the form of classification trees.
In the rotavirus induced BA mouse model, symptomatic animals had a significantly increased hepatic transcription of IL-17.
In this model septic animals had a mortality rate of 56% with death occurring between 18-36 h.
The model animal approach has relied not just on brilliant detective work, but also on painstaking craft.
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