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In our systemic mouse infection model, animals do not succumb to C. glabrata infection, which allows for long-term experiments to observe competition of mutants within a pool.
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Therefore we conclude that, in our model, animals did not suffer severe pain but rather mild-to-moderate pain.
But in neurotoxicant models, the animals do not develop the full range of clinical and pathological features of the human disease, especially those that result from nerve cell death in other brain regions.
Therefore, the surgical menopause models using younger animals do not capture the age-associated adaptations in the tissues, which limits the interpretation of the findings.
Therefore, there is an urgent need to validate existing in vitro models using data from animal models, although these animal models do not fully simulate the physiology of humans.
For obvious ethical reasons, in vivo models cannot be used in human pregnancy, and animal models do not perfectly reflect human physiology.
There are many developmental diseases that cannot be studied by animal models since the mutant animal does not recapitulate the human phenotype.
We acknowledge that this experimental model, like most animal models, does not recapitulate all aspects of clinical VILI.
While animal models do have species-dependent bone formation rates, typically, the first 4 weeks of most animal studies are used to assess the host's response to the implant (biocompatibility).
Meanwhile, innumerable animal lives are lost, and the process often fails to predict human responses because traditional animal models do not accurately mimic human physiology.
The development of anti-influenza drugs has been limited by the fact that animal models do not accurately reflect the infection mechanisms influenza viruses engage in humans.
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CEO of Professional Science Editing for Scientists @ prosciediting.com