Sentence examples for model and tumor from inspiring English sources

Reflecting the good potency and PK profile, orally administrated compound 1o showed significant pharmacodynamic (PD) marker reduction (at 0.3 mg/kg, bid) in HCT116 mouse xenograft model and tumor growth suppression (at 1 mg/kg, bid) in 786-O mouse xenograft model.

Agreement between this model and tumor data is surprisingly close; electromagnetic spiral patterns generated were identical at the spiral vascular arrangement in connection with GTCHC complexes in malignant tumors.

The in vivo anti-angiogenic activity of THL was also demonstrated in the Matrigel plug model and tumor xenograft in NOD-SCID mice.

Since most studies used αVβ3-positive tumor cells to establish the tumor model, and tumor vasculature represents about 5%% of the volume, the effectiveness of the RGD-based PET probe to detect angiogenesis requires greater validation.

When choosing an in vitro model for cancer, the most important criteria are that the model reflects the tumor type it is supposed to represent and that the correlation between tumor model and tumor type is high.

The PC-3 model has a relatively slower growth rate than does the 4T1.2 tumor model, and tumor growth was more effectively controlled by the different treatments in the PC-3 model.

This is further supported by preclinical studies showing a direct correlation between variable liposome deposition in rat xenograft models and tumor response to PLD [11].

Topics included drug design, target identification, early detection, cancer stem cells, microRNAs, genome wide approaches to determining risk and outcome, mouse models, and tumor microenvironment.

Our work supports and expands over a decade of research that has proven that pp32 acts like a tumor suppressor gene in multiple models and tumor systems [8], [9], [11], [12], [13], [30], [31], [32] (Figure 7).

When gadomelitol was used as contrast agent, significant positive correlations were found between the parameters of both pharmacokinetic models and tumor IFP.

Recent studies in preclinical models and tumor biopsies from patients demonstrate that treatment with mTOR inhibitors leads to up-regulation of AKT phosphorylation [74], [75].