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This division drastically increased the accuracy of the model and reduced its relative error.
With the presented approach (PBPK model and reduced sampling schedule), an accurate estimation of the absorbed dose in the kidneys may be achieved by using only two measurement time points, i.e., 4 h and 2 d (Fig. 2).
Structure activity relationship studies led to the identification of 10c, which was efficacious in a diabetic ob/ob mouse model and reduced fasting and non-fasting blood glucose levels after ip dosing.
Because of the error bound between the full-order model and reduced order model, two Kalman state estimators are applied in the control scheme to achieve better system performance.
Global sensitivity analysis quantifies the importance of each input parameter, which can lead to insight into the model and reduced computational cost; commonly used sensitivity metrics include Sobol' total sensitivity indices and derivative-based global sensitivity measures.
To compare the two models, one can use a conditional R2, namely R 2 = 1 − ∑ Y − Y ^ F u l l m o d e l 2 / ∑ Y − Y ^ R e d u c e d m o d e l 2, where the full model is the intercept model and reduced model is the no-intercept model.
Similar(37)
The deal will buy CIT some time to restructure its business model and reduce its voluminous debt load, after the company failed to win crucial concessions from Washington regulators.
ProPublica just received a three-year grant from the John S. and James L. Knight Foundation to help it build a sustainable business model and reduce its reliance on the Sandlers, who are taking the lead in the effort to find more diverse financing.
As a result, Sony has been trying to restructure its business model and reduce its costs.
This is generally the case to simplify the model and reduce the complexity of the equations.
That could mean someday obliterating the firm's pricing model and reducing the upside it enjoys from having thousands of staffers toiling endlessly at customer accounts.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com