Both were lively comedies of intrigue, adapted from Spanish models; and Le Menteur is the one outstanding French comedy before the plays of Molière, Corneille's young contemporary, who acknowledged its influence on his own work.
Indeed, chemotherapeutic compounds like doxorubicine, 5-fluorouracil, and CPT-11 showed a synergy in apoptosis induction with TRAIL, and suppressed tumour growth in animal models (Gliniak and Le, 1999; Keane et al, 1999).
We performed a thousand replications each time estimating the age-specific transition rates by the hazard models and the LEs by the illness-death models.
PhyML was run with the LG evolutionary model (Le and Gascuel 2008) and a gamma distribution with four categories of substitution rates (Γ4) and an estimated alpha parameter.
Two maximum-likelihood analyses were performed, using the standard LG-I amino acid substitution model (Le and Gascuel 2008) and the Mollicutes-optimized MOLLI60 substitution model (Lemaitre et al. 2011), respectively.
LG model (Le and Gascuel 2008) was selected, and a four-category GAMMA distribution was used.
A maximum likelihood tree was also calculated by PhyML (Guindon et al. 2010) and the LG amino acid substitution model (Le and Gascuel 2008) with four rate categories as suggested by the Akaike information criterion (AIC) implemented in Treefinder (Jobb et al. 2004).
Using the AIC scores, we selected the LG model (Le and Gascuel 2008) with α = 3.27 and P = 0.01.
Amino acid sequences of single-copy genes were extracted, aligned with MUSCLE, concatenated, and used for PhyML phylogenetic analyses with the LG model (Le and Gascuel 2008).
According to the results of ProtTest analysis, LG model (Le and Gascuel 2008) with a proportion of invariable sites and a gamma-shaped distribution of rates across sites (LG+I+G) was selected for MenF and MqnC, and LG+G was selected for MenB, MenC, and MqnAD.
