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Tβ4 was shown to decrease apoptosis in an ethanol-treated corneal epithelial model and inhibit activation of NF-kB during TNF-α stimulation in human corneal epithelial cells.
Anthocyanins decrease phospho-GSK3-beta and beta-catenin expression in an in vivo tumor xenograft model, increase AMPK activity in this model, and inhibit cell migration and invasion, possibly by inhibiting MMP-2 (in vitro) and the panendothelial marker, CD31 (in vivo).
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They prevented the extent of swelling in the TPA-induced ear edema model and inhibited MPO activity, showing similar potency to that of the widely used anti-inflammatory drug indomethacin.
It is not clear however whether KD can actually reduce serum uric acid levels in hyperuricemia models and inhibit XO activities.
The most potent of these L39, a Δ4-3-one-androstane derivative, is able to lower androgen levels effectively in animal models and inhibit tumour growth of androgen-dependent cancer cells in both in vitro and in vivo studies.
Both PGRN and Atsttrin prevented inflammation in various arthritis mouse models and inhibited TNFα-induced intracellular signaling pathways.
Our previous studies proved that DSF/Cu exerts increased anti-tumor effects on non-small cell lung cancer (NSCLC) xenograft models, and inhibits NSCLC recurrence driven by ALDH-positive cancer stem cells.
Liposome-encapsulated curcumin suppressed pancreatic carcinoma growth in murine xenograft models and inhibited tumor angiogenesis in vivo.
Furthermore, native GLP-1 stimulates β-cell proliferation in animal models and inhibits apoptosis in vitro, which may increase β-cell mass and function (2).
Carnosine was recently reported that it retarded tumor growth in vivo mouse models and inhibited the proliferation of colon cancer cell in vitro[ 6, 7].
PCI-32765 treatment resulted in potent inhibition of joint synovitis, cartilage, and bone destruction in both CIA and collagen antibody-induced arthritis (CAIA) models, and inhibited inflammation and vasculitis in Arthus and passive cutaneous anaphylactic (PCA) assays.
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