These models have been formulated on top of Eclipse Modeling Framework and Graphical Modeling Framework (Eclipse Consortium 2011).
The numerical modelling and graphical simulations were also carried out and the results are also provided that demonstrate the correlation between the experimental results and physical responses.
To integrate the two distinct simulation platforms, several technical challenges needed to be overcome including reconciling differences in update frequency, coordinate systems, and the fidelity levels of the vehicle dynamics models and graphical rendering requirements of the two simulators.
A team with adequate resources can tackle a completely new concept through parallel activities, iterating between back-of-envelope calculation, laboratory rigs, materials tests, computer modeling, and graphical work.
Moreover, a comparison, based on intra-observer variability, was made between kinetic modelling and graphical analysis.
As kinetic modelling, using non-linear least squares optimisation, is computationally expensive and sensitive to noise, a comparison will be made between kinetic modelling and graphical analysis to quantify [18F]FCho uptake in tissues.
The Boolean export and simulation complement the existing rxncon exports to SBML, rule based and agent-based models, and graphical formats such as the SBGN formats.
All molecules investigated in this study were built with the molecular modeling and graphical user interface package Maestro (v. 9.3, Schrödinger, New York, NY, 2012).
All statistical analysis, modelling and graphical diagnostics to check for compliance with the arithmetic assumptions of the tests and transformations were performed using the R Program (R 2.3.1; R Foundation for Statistical Computing, Vienna, Austria).
