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In the allele model and genotype models, significant associations were found when all studies were pooled in the overall population (Table 3).
Model association analysis found genotypes "T/C" and "C/C" in the dominant model and genotype "T/C" in the overdominant model of rs2808630 associated with reduced LC risk.
We also ascertained a significant allele "C" and genotypes "T/C" and "C/C" in rs2808630 in the dominant model and genotype "T/C" in the overdominant model that is protective against lung cancer development.
As can be seen from the Panels 1 3 of Figure 3, for all the phenotype disease models, when both underlying tests were almost equally powerful (e.g. Panel 1 haplotype disease scenario "Common" model, and genotype disease scenario "Both" and "Common" models), the power of both MinP-val and SumP-val were on the same level or even higher than those of the underlying tests.
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Notwithstanding this point, previous studies reported that, when used, both mathematical modeling and genotyping approaches yielded comparable results [ 21, 40].
The SNP rs3740199, rs1044122, and rs1278279 were found with no statistical difference in comparing the genotype frequencies between the case and control groups no matter for which model of comparison (allele level, dominant model, recessive model, and extreme genotype model).
The SNP rs1871054 was found with increased risk of OA susceptibility in comparing the genotype frequencies between the case and control groups no matter for which model of comparison (allele level, dominant model, recessive model, and extreme genotype model).
This is because, according to the imprinting model and the genotype codes, the maternal and paternal allelic substitution effects are written as α− i and α+ i.
If the coefficients of the markers are set to zero or a low value in the training phase, they are excluded from the model and their genotype information is not required during the breeding phase.
There were no apparent differences between model and forage genotypes of Lotus with regard to the range of tolerance/sensitivity, growth inhibition, salt accumulation and nutrient status under salt stress (Figures 1 to 3).
Strandén and Christensen showed that different allele coding methods lead to the same inference of marker effects when the general mean is included in the model and all genotypes are observed [ 25].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com