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The composite scaffolds were tested in vivo in a large-scale calvarial defect model, and bone regeneration was evaluated for up to 14 weeks after implantation.
The CIA model and bone marrow chimeras were used to determine the cellular source of u-PA required for the arthritis development.
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Thus, BMPs are key molecules that control bone modeling and bone remodeling.
Mesenchymal stem cells (MSCs) are well known for playing a pivotal role in bone growth, bone modeling, and bone remodeling.
The disease is also associated with a homeostatic imbalance between bone modeling and bone resorption.
Statistical models and bone mineral density (BMD) captured by Dual-Energy X-ray Absorptiometry (DXA) are used for in vivo osteoporotic fracture risk assessment [ 4, 5].
The present study assessed different screw configurations in terms of their rotational and bending stability in an artificial bone model and cadaver bone.
In this work, we investigated angiogenesis in 3D scaffolds by in vivo multiphoton microscopy during bone formation in a murine calvarial critical bone defect model and evaluated bone regeneration 8 weeks post-implantation.
More recently, another study showed ectopic osteoinductive properties of calf fetal growth plate in a rat sub-muscular model [31] and bone healing enhancement in a rabbit bone defect model [32].
Furthermore, these scaffolds promoted bone formation in a mouse calvarial defect model and the bone formation was enhanced by addition of rhBMP-2.
The significance of expression between the mouse model and human bone metastases was estimated using SubMap [ 31].
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