For the purpose of this review, these model systems will include in vitro culture of animal cells and explants, heterotopic models of chondrogenesis, and articular cartilage defect models.
117 In rheumatoid arthritis models, overexpression of cathepsin K led to spontaneous synovitis and cartilage erosion, while cathepsin K-null mice in the collagen-induced arthritis model revealed decreased bone and articular cartilage resorption, suggesting that cathepsin K inhibition could be beneficial in this context.
Three-dimensional models of the bones and articular surfaces were created from the pre- and postactivity scans.
Caminal, M. et al. Use of a chronic model of articular cartilage and meniscal injury for the assessment of long-term effects after autologous mesenchymal stromal cell treatment in sheep.
Although the low-dose MIA model mimics articular cartilage and subchondral bone pathology of human OA, like any other animal model of OA it does not fully mirror human OA.
In this study, we found that intra-articularly injected ADSCs inhibited cartilage degeneration progression in a rabbit OA model, and homed to intra-articular soft tissue (the subintimal layers of the synovium, ligament).
Thus, in this experiment, we studied and compared the effects of Glc, GlcA, GlcN-S and GlcN-HCl in two models using IL-1β to induce inflammtion: first in a porcine cartilage explant model, and second, in a human articular chondrocyte (HAC) culture model.
The FDA recognised that there is no perfect animal model of articular cartilage injury and recommended contacting them prior to nonclinical testing in order to best determine and define specific study design components.
By combining ACPC- and MSC-laden bioinks, a bioprinted model of articular cartilage was generated, consisting of defined superficial and deep regions, each with distinct cellular and extracellular matrix composition.
A recently developed near-infrared fluorescence-labeled folate probe (NIR2-folate) was tested for in vivo imaging of arthritis using a lipopolysaccharide intra-articular injection model and a KRN transgenic mice serum induction mouse model.
