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Now that the consumer matters more, the model also matters more.
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When co-administered with the antibiotic Rapamycin, 8 which is known to suppress spontaneous remyelination, the cuprizone/rapamycin protocol in mice is a robust animal model of CNS demyelination and MS. 8 In addition to demyelination of the white matter, this model also features extensive gray matter demyelination in neocortex, piriform cortex, and hippocampus.
The model also simulates surface soil organic matter (SOM) fractions that presumably vary in age and chemical composition.
A second model also included auxiliary input data (soil clay, pH, organic matter) as potential modeling variables.
The SBCA model also accounted for the time series resulting from structured noise in the average BOLD signal in white matter (WM), grey matter (GM), and cerebrospinal fluid (CSF) and head movement (six regressors resulting from McFLIRT motion correction).
Sheer inclination also matters.
But politics also matters.
But inflation also matters.
Timing also matters.
Scale also matters.
Message also matters.
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