In addition to inducing tissue damage, our Paneth cell ablation model also induced an inflammatory response that is consistent with NEC, as tested by protein expression levels.
It has to be taken into account that this model also induced severe damage to the liver including bile duct hyperplasia, inflammatory cell invasion and parenchymal necrosis.
Breach of self-tolerance to joint antigens has been observed in a model of mono-arthritis, a model also induced by an inflammatory response to an antigen unrelated to the joint [ 30], the hypothesis being that joint auto-antigens are exposed to or released from the inflamed joint during the inflammatory response following antigen challenge.
QD dosing of A66 S in an HCT-116 xenograft model also induced a significant reduction in tumour volume with a TGI of 77.2% of control (P<0.01) at the end of dosing, but caused a non-significant reduction in tumour volume in the U87MG xenograft model (Table 4 and Supplementary Figure S5 at http://www.BiochemJ.org/bj/438/bj4380053add.htm).htm
This triggers the chemical reactions described by our phase field model and also induce each GRN to attain a different attractor in a coevolving way, that is, depending on the values of the external fields in space and time, different attractors are chosen, and this in turn reinforces the changes of the external fields through a reciprocal interaction.
HFS of the vmPFC has not only been demonstrated for memory enhancement in the middle-aged memory deficit rat model, but also induced profound antidepressant-like behaviors in the experimental animal studies (Lim et al., 2015a; 2015a).
Not only does diet-induced obesity increase OA joint pathology in a mouse model, but it also induces anxiety and hyperalgesia, and decreases muscle function and locomotor activity [ 40].
In addition, it suppressed endogenous ERG expression and cellular proliferation in in vitro models and also induced cellular apoptosis in in vivo models.
A study using a canine prostate cancer model showed that Dkk1 overexpression potently inhibited bone growth in a xenograft model, but it also induced primary tumor growth and increased the rate of metastasis [137].
Brief exposure of MDA-MB-231 cells to 15dPGJ2 inhibited tumorigenesis of MDA-MB231 cells in a nude mouse model [ 42]. 15dPGJ2 also induces cytotoxic effects in basal-like breast cancer cells, including MDA-MB231, BT549, and HS578T cells, through PPAR-γ independent mechanisms [ 43].
