After model selection, age, stage of tumor, histological type, surgery and radiation treatment were left in the reduced models.> -wrap-foot>> -wrap-foot>> -wrap-foot> Abbreviations: HR Hazard Ratio, CI Confidence Interval.
In the multivariate model, age, clinical stage, and comorbidity were found to be negatively associated with the survival rate.
To identify genes involved in ACT-response and not simply prognosis, the covariates included in the Cox regression models were age, stage, gender, smoking history and prognosis risk group (P < 0.001), as determined by previously developed prognostic algorithm.
The following variables were included in the multivariate model: age, gender, TNM stage, histological differentiation, CIMP status, MSI status, treatment modality (surgery alone versus surgery with chemotherapy), BRAF mutation, KRAS mutation and MGMT methylation.
In the Cox proportional hazard model we used covariates (age, stage, Lauren's type, type of surgery performed, total albumin level, total lymphocyte count, weight loss, and the time of weight loss) that might influence postoperative morbidity [ 21– 23].
In a multivariate model age and WHO clinical stage were also associated with successful treatment outcome after adjusting for sex, HIV RNA, CD4 cell %, WAZ and HAZ [Table 4].
If there are more than 5% missing answers we will use multiple imputations with the following variables in our model: age, sex, diagnosis, cancer stage, and The World Health Organisations WHO) performance score.
In the recessive model after adjusting for age, stage of disease at diagnosis, adjuvant radiation therapy and oestrogen and progesterone receptor status, Cox regression analysis showed no statistically significant differences in OS (HR = 0.33, 95% CI = 0.10-1.09, P = 0.068), neither did the BCSS differ significantly (HR = 0.36, 95% CI = 0.11-1.20, P = 0.095) (data not shown).
In multivariate analysis modelling EFS, the parameters age, stage and a segmental genomic type were retained in the model, whereas the individual genetic markers were not (P<0.0001 and RR=2.56; P=0.0002 and RR=1.8; P=0.01 and RR=1.7, respectively).
The Husa granodiorites also have high initial Sr ratios of 0.716496, negative εNd(t) value of − 16.5, two-stage model age of 1.89 Ga, variable εHf(t) values of 3.4 to − 18.1 and Pb isotopic compositions similar to lower crustal values.
