Model adjustments were evaluated using three indexes.
Refinement was conducted with Phenix, and manual model adjustments were made with Coot.
Manual model adjustments were carried out in Coot followed by refinement with Refmac and Phenix.
In the final model, adjustments were made for birth weight, maternal atopy, and RS-virus infection.
To see what changes each variable caused to the model, adjustments were made stepwise, adding one variable at a time to the conjoint demography adjusted analysis.
In the model, adjustments were made for age and education, which statistically differed between the groups at the time of randomisation.
Each model was adjusted for other individual level cognitive variables (e.g. for the intention model, adjustments were also made for refusal self-efficacy scale and dichotomous attitude items) since these variables may influence each other [ 8, 15].
Data for lowly expressed genes, whose maximum TMM expression value across samples was less than 10, were removed, and model adjustments were made for pre- and post-globin reduction RNA Integrity Number, and 5′-3′ read skewness.
In the full model, adjustments were made for age at first OGLD prescription, sex, calendar time, number of unique drugs used, and number of hospitalizations in the year before the start of OGLD (0.90 [0.90–0.90]).
In the first model adjustments were made for age (years), sex, smoking (never, former, or current), and level of education (low [primary education], intermediate [lower vocational, secondary general, or vocational education], or high [higher vocational education or university]).
