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bAdjusted model additionally includes stage and grade, restricted to 574 cases and 2,268 controls with available data.

A major difference is that the regression model additionally includes information of parents that are informative (that is, heterozygous) for MICA and that are also heterozygous for HLA-DRB1 risk alleles.

The first model tests the unadjusted effect of sarcopenia on the outcome, the second model adds age, sex, race, and BMI to the equation, and the third model additionally includes depression.

The waist circumference-related point-based biochemical model, additionally including HDL cholesterol (3 points) and triglycerides (2 points), is shown in Additional file 1, Table S1.

The extended model additionally included family history; this model was compared with the reference model.

The second model additionally included history of CVD or CVD subtypes (model 2).

Second, a minimal model additionally including the covariates sex and age was calculated.

First, adult BMI was added to the model that included all these potential confounders, and a subsequent model additionally included waist circumference.

The best-fitted reference model was composed of baseline HOMA-IR and BMI, and for men the model additionally included apoB and physical activity index.

The second model additionally included an indicator of planned birth other than for hypertension, and a predicted trend was obtained in the same way.

To explore the potential influence of patient case-mix, the second model additionally included case-mix variables (patient age, gender, ethnic group and cancer diagnosis).