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The extended model additionally included family history; this model was compared with the reference model.

The second model additionally included history of CVD or CVD subtypes (model 2).

The second model additionally included an indicator of planned birth other than for hypertension, and a predicted trend was obtained in the same way.

To explore the potential influence of patient case-mix, the second model additionally included case-mix variables (patient age, gender, ethnic group and cancer diagnosis).

The best-fitted reference model was composed of baseline HOMA-IR and BMI, and for men the model additionally included apoB and physical activity index.

First, adult BMI was added to the model that included all these potential confounders, and a subsequent model additionally included waist circumference.

The waist circumference-related point-based biochemical model, additionally including HDL cholesterol (3 points) and triglycerides (2 points), is shown in Additional file 1, Table S1.

Second, a minimal model additionally including the covariates sex and age was calculated.

bAdjusted model additionally includes stage and grade, restricted to 574 cases and 2,268 controls with available data.

First, we fitted a simple model including only age and sex (model 1), followed by a model additionally including alcohol consumption, socioeconomic status, fasting status, race, and month of blood sample collection (model 2), and then a model additionally including smoking status, BMI, physical activity, and insulin resistance (i.e., HOMA-IR) in deciles of distribution (model 3).

The first model tests the unadjusted effect of sarcopenia on the outcome, the second model adds age, sex, race, and BMI to the equation, and the third model additionally includes depression.