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In this HI model a substantial glial scar is present in the damaged cortex and remains in the long term accompanied by disruption of neuronal and axonal architecture.
In the present model, a substantial reduction of ICaL (45%) was found to be necessary in the model to give a prolonged CL.
In the transition from the C to the L model, a substantial increase in the number of iterations was offset by a small increase in the time per iteration, so that the overall increase in running time was relatively small.
Even though NRI and IDI increased with additional CpGs included in the model, a substantial proportion of controls, who were supposed to move to lower risk categories, moved to higher risk categories along with cases moving to higher risk categories.
In summary, modeling of excess noise levels in terms of known regulatory interactions shows that, in accordance with our model, a substantial amount of the variation in noise levels can be explained by noise-propagation from noisy regulators, and the regulators we identify as most significantly propagating noise are consistent with existing biological knowledge regarding our growth conditions.
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On the other hand, when a Pvalue threshold of 0.20 was applied to select covariates for multivariate logistic regression during univariate logistic models, a substantial number of spurious independent associations were detected which were not retrieved by any other methods.
In all cases of microsatellite selection (under both demographic models), a substantial trough of k s k (20 ) 2 was observed that was noticeably lower than the background level (supplementary fig. S7, Supplementary Material online).
Although the Cochran Q test provides evidence for (residual) heterogeneity in all the models, a substantial amount is actually explained by between-country differences, as indicated by the larger drop in the I statistics when indicators for country are included as meta-predictors.
In [ 18- 20], optimization techniques are used to determine which reactions can be eliminated from the original model without a substantial alteration of the model behaviour.
The development group was aware of the potential limitations of such a model but believed that this model represented a substantial step forward for considering the "whole of life" treatment of a cancer that will ultimately cause death.
This model offers a substantial improvement over existing models in accuracy and simplification in quantifying pH and surface loading effects on arsenic adsorption.
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