Sentence examples for model a mutant from inspiring English sources

Contrary to the current model, a mutant Ku with low affinity for dsDNA also loses affinity for TLC1 both in vitro and in vivo.

In another mouse model, a mutant carrying this gene was 1,000-fold 1,000-foldent than an isolate without the gene.

Additionally, three mutant model systems were constructed based on the native model: a mutant lacking the β-hairpin (Δ233 240) (sim2, hairpin mutant), a mutant lacking the α-helix (Δ447 460) (sim3, helix mutant), and a mutant lacking both (Δ233 240 and Δ447 460) (sim4, helix-hairpin mutant).

In addition in the Eker rat model, a mutant Tsc2 gene that fails to inhibit mTOR is still able to suppress tumourigenesis (Shiono et al, 2008), and administration of rapamycin reduces the development of macroscopic tumours while having no effect on the number of microscopic precursor lesions (Kenerson et al, 2005).

Note that as shown in figure 1, this mutant is a poor invader in the single death model; a mutant with a higher replicative fitness (λ = 0.9, diamonds) was able to invade the background less than 10% of the time at maximum motility.

Here we characterize two zebrafish models for a severe form of Usher syndrome, Usher syndrome type 1C (USH1C): one model is a mutant with a newly identified ush1c nonsense mutation, and the other is a morpholino knockdown of ush1c.

Specifically, the Dantuma group employed a model expressing a mutant form of ubiquitin (G96V) fused to the N-terminus of GFP, which cannot be cleaved and is instead polyubiquitinated on both the lysine 29 and 48 residues and targeted for proteasome-mediated degradation [24], [35].

To examine the role of APTX in vivo, we modulated the cellular antioxidant homeostasis by generating a mouse model where a mutant form of superoxide dismutase 1 (SOD1G93A) is expressed in an Aptx−/− background.

Probiotic bacteria deficient in the bacteriocin gene are less effective probiotics, as demonstrated in a murine model where a mutant form of Lactobacillus salivarius UCC118 failed to protect against infection with Listeria monocytogenes [ 14].

In an in vivo approach, a transgenic mouse model expressing a mutant variant carrying a duplication of 13 amino acids in the TWINKLE linker region was shown to accumulate multiple DNA deletions, the so-called 'deletor mice' (24).

In the same disease model, a pqsR mutant showed an ∼35% reduced mortality rate compared with the wild type.