Tetanic stimulation (80 mA, 30 sec., 50Hz), the most common used noxious event in clinical studies, was compared to Bromm's pain model, a direct intracutaneous stimulation (80 mA, 30 sec., 2Hz) of Aδ- and C-fibres [1].
Using the obtained binormal mixture model a direct estimate of the true seroprevalence per age category was obtained, making correction for sensitivity and specificity unnecessary.
The results of the present study confirm the hierarchy predicted by the model: a direct comparison of activation for the detection of a contour-preserved versus a contour-violated difference revealed greater activation for processing contour-preserved differences.
In our model, a direct measurement of the host neutrophilic inflammatory response in the infected post-operative joints was obtained by combining the use of a mouse line that possesses fluorescent neutrophils (LysEGFP mice) with advanced in vivo fluorescence imaging techniques [47], [48].
Additionally, in at least one laboratory model, a direct thrombin inhibitor (dabigatran) has been shown to inhibit both invasion and metastasis of malignant breast cancer cells [ 69].
Furthermore, in the MOG35-55 EAE model a direct immunosuppressive role for the non-specific Na+ channel blocker Phenytoin highlighted caution for its use in Clinical Trials as the specific cellular target remains clearly unresolved [ 96].
