Sentence examples for mode of substrate from inspiring English sources

The similar mode of substrate recognition observed in diverse riboswitch classes suggests a common functional mechanism, whereby conformational adaptability enables the RNA to encapsulate the substrate.

Interestingly, two sulfate ions and one diphosphate coordinated with some conserved residues were observed in the active cleft, which affords a better understanding of a possible mode of substrate binding.

As previously reported, the native mycobacterial CoaE shows an ordered mode of substrate binding with DCoA acting as the leading substrate and ATP following it.

Indeed, given IDE's unusual structure, mode of substrate processing and sensitivity to endogenous cofactors [23], it may ultimately be possible to identify compounds that operate in one physiological context but not others (e.g., intracellular vs. extracellular).

We find that the LexA Pa active site possesses a unique mode of substrate recognition.

20 Docking calculations were carried out using AutoDock v4 21 in order to elucidate the mode of substrate binding.

The observed binding mode of substrates indicates how the first reaction intermediate, the Schiff-base conjugate, is formed.

However, the subtle structural differences that have recently been observed across a variety of families shed light on their functional diversity, including variations in mechanism of action, differences in the modes of substrate binding, and substrate-assisted orientation of catalytic residues.

Many of these families are functionally heterogeneous, containing members that differ in substrate specificities as well as sites and modes of substrate cleavage.

Understanding the structural biology of protein kinases in detail, including their commonalities, differences and modes of substrate interaction, is necessary for designing high quality inhibitors that will be of true use for cell biology and disease therapy.

These interactions allow for two distinct modes of substrate binding.