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Neither of these genes might actually be a target of hsa-miR-641; there may also exist stronger regulating elements that control their expression, or the primary mode of silencing in that specific situation may be through translational repression.
hsa-miR-124 is an miRNA known to be silenced by methylation in many cancers, and Wilting et al. (2010) proved that this mode of silencing frequently occurs in cervical lesions as well [ 70].
These findings strongly suggested that T. gondii employs the Tg-miRNA species-specific mode of silencing actions: transcript degradation by Tg-miR-60a, and translational suppression by Tg-miR-4a.
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It is likely that other modes of silencing may also emerge as common mechanisms for ncRNA-mediated silencing.
These modes of silencing and escape gene activation are very different from those in female X chromosome inactivation.
Besides, sneering at the mode of protest rather than examining what the protest is about is an old method of silencing and cowing.
The key targets of miRNA would have canonical matching and these miRNAs employ the similar mode of gene silencing as siRNAs through mRNA cleavage and degradation [11,12].
Promoter region hypermethylation associated with transcriptional loss is an alternative mode of gene silencing for several tumour-suppressor genes (Zingg and Jones, 1997; Baylin et al, 1998; Herman, 1999).
Soybean seed coats and hilum color are regulated by chalcone synthase (CHS) genes that control the anthocyanin and proanthocyanidin pigments via a posttranscriptional mode of gene silencing [ 33, 34].
She has returned to her customary mode of aggressive silence.
BT-CMS is restored by two related PPR motif genes, Rf1a and Rf1b, by blocking ORF79 production through distinct modes of mRNA silencing: endonucleolytic cleavage of the dicistronic B-atp6-orf79 mRNA by RF1A and degradation by RF1B.
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