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All 90 outbreaks were considered when describing mode of secondary transmission.
For statistical analyses, only the 67 outbreaks with a known mode of secondary transmission were included.
Where no secondary transmission was reported (N/A), outbreaks were not included in mode of secondary transmission analyses.
Results from this study point to a conserved mode of secondary metabolite (SM) biosynthesis regulation in fungi by chromatin modifications and the formation of facultative heterochromatin.
Allopolyploidy, i.e. hybridization followed by chromosome doubling, is a frequent mode of secondary speciation in vascular plants (Leitch and Bennett 1997; Haufler 2008).
The most common mode of secondary transmission was person to person within the home (46%), but 23% of outbreaks did not have identified secondary cases (Table 1).
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There was a significant difference between modes of secondary transmission in the rate of secondary cases (p < 0.001, Figure 3d).
There were also significant differences in median age between modes of secondary transmission (Fisher's Exact p < 0.001).
Secondary case rates differed statistically significantly between modes of secondary and primary transmission and median age categories (all p < 0.001), but not between countries (p = 0.23).
When the interaction terms were removed, there were statistically significant differences in the rate of secondary cases between modes of secondary transmission (p < 0.001) and median age (p < 0.001).
There were statistically significant differences between modes of secondary transmission in the log-transformed numbers of primary and secondary cases (p < 0.003) cases, but not in ill and confirmed cases (p > 0.29, Table 2).
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