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This second mode of repression depends on a H3K36-specific HMTase, MES-4.
This raises the possibility that Eds1 also is involved in glucose control of gene expression, which could explain its unusal mode of repression by Mig1 and Mig2.
miR172-mediated cleavage of mRNAs of these target genes has been detected [ 21], but there is strong evidence to suggest that the primary mode of repression of these target genes by miR172 is translational inhibition [ 13, 14].
We interpret this as correlation rather than causation, i. e. the Pho4 sites are found in these genes because they are involved in phosphate metabolism, and not because Pho4, directly or indirectly, contributes to the redundant mode of repression.
Indeed it is through such a mode of repression that E-cadherin levels are diminished by HBV (61– 63), Hepatitis C virus (HCV) (64, 65) and Epstein-Barr virus (EBV) (66– 66).
This is consistent with recent reports that contrary to what was previously thought, decreasing mRNA levels is the main mode of repression for mammalian microRNAs (Guo et al., 2010).
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Just one more instance of the old modes of repression being alive and well in Egypt.
These findings suggest that Gro employs both Rpd3-dependent and Rpd3-independent modes of repression.
Multiple modes of repression could allow Gro to fine tune gene activity in response to promoter context and cellular environment.
Three modes of repression of targets have been proposed in plants [ 12].
The exact mechanism of repression however remains to be resolved, as three different modes of repression are currently known [ 80].
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CEO of Professional Science Editing for Scientists @ prosciediting.com