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Molecular docking studies were performed to explain the binding mode of proteins and synthesized complexes.
In addition, the rather weak Raman signal at 1126 cm-1 can be assigned to the C-C the stretching mode of proteins.
The Raman spectra of both normal and disease populations are shown in Fig. 1 (normalized to CH2 bending mode of proteins and lipids at 1443 cm−1, as described below).
In addition, the epidermis PCs load on the phospholipid and nucleotide band near 698 cm−1, the 936 cm−1 peak of proline, valine, and glycogen, the 1095 cm−1 peak of the DNA phospholipids backbone, and the CH2 bending mode of proteins and lipids near 1448 cm−1.
Some bands can be assigned to superpositions of signals from different biomolecules with CaDPA, for example the bands at 821 cm−1 (superposition of the ring-breathing mode of tyrosine with the CaDPA carboxylate stretching mode), at 1450 cm−1 (the CH2/CH3 deformation mode of proteins and lipids), and at 1578 cm−1 (ring vibration of guanine and adenine with pyridine ring vibrations of CaDPA).
Similar(54)
This mode of protein-DNA interaction provides a potential target for future antimicrobial drug design.
The factors that determine the tempo and mode of protein evolution continue to be a central question in molecular evolution.
Type-1 secretion systems (T1SSs) represent a widespread mode of protein secretion across the cell envelope in Gram-negative bacteria.
Molecular docking study evidenced a possible mode of protein binding fully coherent with the one observed in crystalline co-structures of known ligands.
Structural biology insight regarding the binding mode of protein kinase inhibitors is valuable for the design of molecules possessing superior selectivity, efficacy and tolerability.
While DDAB and ABT-737 are distinctly different ligands, the compounds share strong similarities in their mode of protein interactions.
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