Furthermore, the genome-centric view of metabolism is identifying new modes of metabolic regulation, such as the indirect effects of interfering RNAs, and these will need to be incorporated in models of metabolism and its control.
Reliable kinetic modes of metabolic networks will accelerate drug target identification and rational drug development.
Minimal cut sets (MCS) represent "elementary failure modes" of metabolic networks [ 5].
In order to investigate the system-level change in response to the growth conditions we identified modes of metabolic operation under autotrophy and mixotrophy in terms of active reaction presented the non-zero flux value of the simulations.
This discrepancy with our results may be attributed either to the mode of the metabolic acidosis induction (lactic acid versus hydrochloric acid), or to the species-specific differences (dog versus pig).
There is however a wide variety of opinions regarding the cellular status (prokaryotic or not), homogeneity and complexity of this entity (the "community" concept [ 9]), depending on assumptions made on its mode of emergence, metabolic evolution and the nature of its genetic material.
Metabolic CNs were employed, with genome-wide association mapping in Arabidopsis accession lines, to study the mode of inheritance of metabolic traits in seeds and fruits and their interactions [ 38].
Our method can easily operate on large, genome-scale networks since it does not require all relevant modes of the metabolic network to be generated.
First, computationally extensive analyses, such as full enumeration of elementary modes for metabolic pathway analysis, may only be tractable in smaller models.
