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Furthermore, a DNA retardation assay did not support a different mode of killing action in different concentrations of β-casein 197 as was reported for AMPs such as human β-defensins and lasioglossins, which have the ability to bind DNA (Bandyopadhyay et al. 2013).
Resistance is accompanied by tolerance to drug-induced apoptosis not only against the selective drug but also against drugs sharing a similar mode of killing.
Toxins found in O. polyrhachis-furcata's genome are for many enterotoxins, suggesting that oral toxicity may constitute a mode of killing for our fungus.
This cross-tolerance leads to a facilitated emergence of cross-resistance against other drugs that have different cellular targets but similar mode of killing.
The dichotomy in the mode of killing between antileishmanials was further reinforced by the observation that cells resistant to SbIII, MF and AMB were tolerant to apoptosis not only against the initial selective drug but also against all drugs sharing a similar mode of killing.
Our results are suggesting two types of drug-induced death in Leishmania, and are linking the mode of killing to tolerance to cell death and to a facilitated emergence of multidrug resistance.
Similar(50)
The gastrointestinal (GI) tract is protected by a network of antimicrobial peptides (AMPs) located in strategic areas of the GI mucosa, with different modes of killing, timing of activation, and intervention.
P. aeruginosa grown on different media exhibited distinct modes of killing termed slow and fast killing.
Our data provide a rationale for combining drugs with different modes of killing.
They're terrifying, require multiple people to take down, and even when you've pumped them full of lead, they default to a kamikaze mode capable of killing you instantly.
Rituximab binds the CD20 antigen on the surface of B cells and has three main elements that contribute to its mode of action of killing the targeted B-cell once binding to CD20 has been achieved [ 26].
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com