Based on the character of the ligand molecules and the coordination mode of the iron atoms, we assign our five structures in a different states in ADO catalytic reaction below.
Furthermore, the coordination mode of two iron atoms in WT-HP structure shows a similar pattern to that observed for the R2 protein of ribonucleotide reductase (RNR-R2), in which the oxo bridge and the coordinated water exist at the di-iron site in the oxidized structure, while both are absent in the reduced structure (Logan et al., 1996).
Genes were analyzed as a whole and also as subgroups based on their potential mode of regulation (iron dependent/independent and activation/repression).
Agglomeration of metallic and carbon particles is observed in two distinct modes: attachment of iron primary particles (5 10 nm in diameter) to carbon agglomerates, and coagulation of iron agglomerates (20 200 nm in diameter) with carbon agglomerates.
The second NEAT domain of IsdB is structurally similar to other heme binding NEAT domains, and heme-iron is coordinated by a tyrosine residue as predicted; however, we have also shown that Met362 coordinates the heme-iron on the distal side, resulting in an unprecedented mode of heme-iron coordination.
We determined the 1.45 Å resolution crystal structure of heme-bound IsdB-N2 and discovered a new mode of heme-iron coordination, with protein ligands provided by both a Met and a Tyr.
The substitution of cobalt for iron revealed an uncommon mode of non-heme iron binding trapped by the non-catalytic Co2+, which, we postulate, may be transiently present in the native enzyme during the catalytic cycle.
In this paper, we present a new test approach for determining the mode II (shear mode) fracture toughness (KIIC) of iron powder compact.
The aim of this study was to explore efficacy and safety of different modes of administration of iron isomaltoside 1,000 (Monofer, Pharmacosmos A/S, Holbaek, Denmark) compared with oral iron sulfate for treatment of IDA in IBD patients.
