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Mode of insulin therapy changed importantly during the study period (Supplementary Fig. 1).
Several studies assessed the impact on perinatal outcomes of mode of insulin treatment.
The improvement was not completely explained by changes in the mode of insulin treatment.
Duration of diabetes and mode of insulin administration were obtained from chart review.
The improvement in glycemic control was not fully explained by demographic factors and changes in the mode of insulin treatment.
DISABKIDS results were related to age, gender, duration of diabetes, mode of insulin delivery and metabolic control.
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These studies suggest that using rt-GCM may have a favorable impact on glycemic control regardless of the methods of insulin delivery; however, as pointed out as a limitation of the review, the current literature does not allow a comparison of rt-CGM versus SMBG in patients only using CSII or only using MDI because the modes of insulin delivery were mixed (18).
Patient preference studies comparing drugs of the same class but having differing dosing frequencies have been performed in various disease states including: diabetes (e.g. comparing differing modes of insulin delivery) [ 13]; gastro-esophageal reflux disease [ 14]; osteoporosis [ 15- 19] and irritable bowel syndrome [ 20].
High fat diet (HFD) feeding is a common mode of inducing insulin resistance in rodents that rapidly causes progressive metabolic dysfunction [7], [8].
Later, Kodama et al. [ 4] described another mode of inducing insulin resistance in rats by substituting streptozotocin for alloxan [ 4].
We identified a subset of classifier genes that can be used to define the primary mode of action of insulin analogues.
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