Sentence examples for mode of indirect from inspiring English sources
Proposed HU-induced miRNAs-mediated mode of indirect HbF regulation through critical regulators (MYB/KLF-1/BCL11A) and possibly directly modulating HbF.
Interestingly, the putative target genes of the positive T-DMR are enriched for negative regulators such as transcriptional repressors, suggesting a novel mode of indirect DNA methylation inhibition of expression through transcriptional repressors.
This mode of indirect trans regulation may be the most common form of gene regulation but also the hardest to detect except in well defined genetic backgrounds such as congenic mice.
One mode of indirect use of NO2− and NO could be their dismutation (formally an 'internal' reduction of N and oxidation of O) leading to O2, according to the following equations: (1) (2) O2 could then be used for an alkane monooxygenase reaction (alkane hydroxylation).
The associated variants did not exhibit pronounced direct effects on gene expression in the cell type studied, indicating an alternative mode of action, indirect association or tissue-specific effects.
The abiding impression left by the allegorical mode is one of indirect, ambiguous, even enigmatic symbolism, which inevitably calls for interpretation.
Still, also other modes of an indirect use of N O species for alkane activation can be envisaged.
Development of allosteric inhibitors into efficient drugs is hampered by their indirect mode-of-action and complex structure kinetic relationships.
In such case of indirect mode, nutritive value of the food product and colour is retained.
Also for some molecules with a direct genotoxic mechanism, a non-linear dose genotoxic response with a range of non-mutagenic low concentrations and a NOGEL has been found in vitro, as it is typically seen for molecules with an indirect mode of genotoxicity [12, 13].
The indirect mode of regulation through a secondary signal, such as ATP produced by an interconnected network of neurons or macroglia, is also consistent with a broader, rather than local, spatial range of regulation.
