Sentence examples for mode of inactivation from inspiring English sources

The present structures confirm that the mode of inactivation observed originally in P. falciparum proplasmepsin II, i.e. an incompletely formed active site, is a true structural feature and likely represents the general mode of inactivation of the related proplasmepsins.

Although this class of inhibitor has been in use for several decades, the mode of inactivation had not been determined for an enzyme that uses an N-terminal nucleophile.

The detailed mode of inactivation is still, however, unknown.

Mutations and hypermethylation as mode of inactivation were largely excluded.

A unique feature of the TP53 gene compared with other tumor suppressor genes is its mode of inactivation.

Gene mutation is a common mode of inactivation of TSGs; however, we did not detect a single mutation in 10 PaCa cell lines tested.

In contrast, the fast mutation rate of miR529 and its high gene loss rate are two major modes of inactivation of miR529 family members [ 23].

Since complex karyotypes frequently contain deletions of the chromosomal region 12p13 encompassing the tumor suppressor genes ETV6 and CDKN1B, we aimed to unravel their modes of inactivation in CK-AML.

To further determine the modes of inactivation of ETV6 [NM_001987] and CDKN1B [NM_004064], we performed mutation analyses of all coding exons of ETV6 in 56 patients and of CDKN1B in 67 patients with and without 12p13 deletions for which DNA was available (Additional file 1: Table S1).

101 Interestingly, the mode of PARP1 inactivation may impact the biological consequences.

This mode of TrxR1 inactivation has been proposed to be an important mechanism in the anticancer activity of cisplatin.