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However, clarity on the form of the expected causal relationship, the parameter identification strategy, and the mode of hypothesis testing is required to overcome a number of conceptual and methodological problems.
But Barnes finds the omission of the Mode of Hypothesis philosophically troubling, given that it 'is a mode of the first importance to the Pyrrhonists' (1990a: 119), and most discussions of the Five Modes mention the system of the Two Modes only in passing, especially since Sextus never employs them explicitly during his discussions of dogmatic philosophical positions.
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Finally, the highly significant associations between basal gene expression variability and chemical-induced toxicity suggest plausible mode-of-action hypotheses for follow-up analyses.
Topics that affect the interpretation of a properly conducted carcinogenicity study include the thoroughness of the histopathologic evaluations, the statistical analyses, and the appropriate application of mode-of-action hypotheses.
Data obtained from either in vitro cell-based or in vivo systems-based DNT alternatives may provide insights into relevant cellular, molecular, and regional targets, informing mode-of-action hypotheses and identifying potentially vulnerable developmental stages, thereby refining and reducing mammalian in vivo testing.
This procedure maximized use of an extensive body of relevant and reliable literature on MTBE with evidence supporting or opposing a given mode of action hypothesis.
A number of research efforts on specific chemicals that were designed for risk assessment purposes have employed mechanism or mode of action hypothesis testing and generating strategies.
These findings provide support to the mode of processing hypothesis (Watkins and Moulds 2005) that it is the processing mode, and not the degree of self-focus, that influences cognitive consequences in depression.
Recently, time-dependent BD processes have attracted more attention as a mode of performing hypothesis-driven research [ 42– 42].
Nevertheless, resistant mutant selection of MDR-sup S. pombe provides the means for developing mode of action hypotheses that do not require any chemical modification of the bioactive compound, preliminary prediction of the target, or construction of a custom-made genetic library, thereby serving as a convenient alternative approach for target identification studies of cytotoxic natural products.
Fransson, P. Spontaneous low-frequency BOLD signal fluctuations: An fMRI investigation of the resting-state default mode of brain function hypothesis.
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